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“I would not make water-based my first choice for a hand job, for instance,” says Queen, adding, “and they’re not great if you’re playing in water—because they’ll wash off too easily, even if you’re not fully submerged.” You might also be sensitive to certain ingredients in water-based lubes, but almost all lubes differ in what goes into them, so it’s always smart to try out several samples to find one you love before you invest in a jug o’ lube
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173 Fibroin has similar numbers of hydrophilic and hydrophobic amino acids, so only small perturbations are needed for aggregation or solvation